<p><b>PURPOSE: </b>We examined the correlates and health implications of household food insecurity among Hispanic/Latino youth (aged 8-16 years), a high food insecurity-risk population.</p><p><b>METHODS: </b>Using the Hispanic Community Children's Health/Study of Latino Youth (n = 1,362) and bivariate and multivariate analyses, we examined the correlates of household and child food insecurity and very low food security. We assessed the influence of four sets of risk/protective factors-child demographic, acculturation, socioeconomic, and family/social support. We then examined associations between food insecurity and four health indicators-body mass index, diet quality, depression, and anxiety-and used modification effects to assess whether these associations differed by sex, age, household income, parent nativity, and acculturative stress levels.</p><p><b>RESULTS: </b>We found high rates of food insecurity: 42% of Hispanic/Latino youth experienced household food insecurity and 33% child food insecurity. Moreover, 10% lived in a very low food secure household. Compared with their food secure peers, Hispanic/Latino youth in food insecure households experienced greater parent/child acculturative and economic stress and weakened family support systems. Associations of food insecurity with health outcomes varied by sex, age, household income, parent nativity, and child acculturative stress levels.</p><p><b>CONCLUSIONS: </b>Food insecurity is highly prevalent among Hispanic/Latino youth and has detrimental health implications, especially for girls, older youth, and youth experiencing acculturative stress. Reducing food insecurity and improving health among Hispanic/Latino youth will likely require comprehensive policies that address their multiple migration, familial, and economic stressors.</p>