<p><strong>BACKGROUND: </strong>&emsp;Individual cardiovascular disease (CVD) risk factors (RFs) have been associated with hearing loss (HL). The relationship to aggregate risk is poorly understood and has not been explored in the Hispanic/Latino population.</p><p><strong>PURPOSE: </strong>&emsp;The aim of this study was to characterize the association between aggregate CVD RF burden and hearing among Hispanics/Latinos.</p><p><strong>RESEARCH DESIGN: </strong>&emsp;Cross-sectional examination.</p><p><strong>STUDY SAMPLE: </strong>&emsp;Participants (18-74 years; &thinsp;=&thinsp;12,766) in the Hispanic Community Health Study/Study of Latinos.</p><p><strong>DATA COLLECTION AND ANALYSIS: </strong>&emsp;Thresholds (0.5-8&thinsp;kHz) were obtained, and HL was defined dichotomously as pure-tone average (PTA)&thinsp;&gt;&thinsp;25&thinsp;dB HL. Optimal CVD risk burden was defined as follows: systolic blood pressure (SBP)&thinsp;&lt;&thinsp;120&thinsp;mm Hg and diastolic blood pressure (DBP)&thinsp;&lt;&thinsp;80&thinsp;mm Hg; total cholesterol&thinsp;&lt;&thinsp;180&thinsp;mg/dL; nonsmoking; and no diabetes. Major CVD RFs were diabetes, currently smoking, SBP &gt;160 or DBP&thinsp;&gt;&thinsp;100&thinsp;mm Hg (or antihypertensives), and total cholesterol&thinsp;&gt;&thinsp;240&thinsp;mg/dL (or statins). Thresholds were estimated by age (18-44 and ≥45 years) and sex using linear regression. The association between CVD risk burden and HL was assessed using multivariable logistic regression. Models were adjusted for age, sex, Hispanic/Latino background, center, education, income, alcohol use, body mass index, and noise exposure.</p><p><strong>RESULTS: </strong>&emsp;In the target population, 53.03% were female and 18.81% and 8.52% had all RFs optimal and ≥2 major RFs, respectively. Elevated BP (SBP 120-139&thinsp;mm Hg or DBP 80-89&thinsp;mm Hg) was associated with HL in females&thinsp;&lt;&thinsp;45 years (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.14-4.16). Diabetes (OR, 1.37; 95% CI, 1.01-1.84) and tobacco smoking (OR, 1.44; 95% CI, 1.03-2.01) were associated with HL in females ≥ 45 years. The odds of HL were higher for females ≥ 45 years with ≥2 RFs versus those with all RFs optimal (OR, 1.99; 95% CI, 1.12-3.53). Elevated BP (SBP 140-159&thinsp;mm Hg or DBP 90-99&thinsp;mm Hg), but not aggregate risk burden, was associated with HL in males ≥ 45 years (OR, 1.49; 95% CI, 1.02-2.19). No relationships with major CVD RFs were significant in males&thinsp;&lt;&thinsp;45 years.</p><p><strong>CONCLUSIONS: </strong>&emsp;HL is associated with elevated BP in females&thinsp;&lt;&thinsp;45 years, with diabetes and hypertension in males ≥ 45 years, and with diabetes, smoking, and having ≥2 major CVD RFs in females ≥ 45 years. Future studies are needed to examine if these factors are associated with incident HL.</p>