<p><b>BACKGROUND AND OBJECTIVES: </b>Family caregiving is common in U.S. Hispanic/Latino populations. Using the Sociocultural Stress and Coping Model framework, the researchers examined the prevalence, duration, and reported stress levels of caregivers from different heritage groups in the Hispanic Community Health Study/Study of Latinos (unweighted-n = 5,313).</p><p><b>RESEARCH DESIGN AND METHODS: </b>The researchers generated target population specific prevalence and mean estimates of study variables and compared between those who reported caregiving and those who did not. Then, for care providers, the researchers generated prevalence and mean estimates of study variables by Hispanic/Latino heritage. Lastly, they fit a series of survey generalized linear models to examine the associations between the proposed variables and the outcomes reflecting caregiving and caregiving experiences.</p><p><b>RESULTS: </b>Nearly two in five individuals in this study were involved in caregiving. In models adjusting for demographic covariates, participants of Mexican heritage were most likely to report caregiving for others but were less likely to report caregiving for more than 6 months. Older age and foreign-birth were linked to increased odds ratios of providing care. On average, Central Americans and Puerto Ricans reported higher levels of stress associated with caregiving.</p><p><b>DISCUSSION AND IMPLICATIONS: </b>Understanding the nuanced characteristics of caregivers from varying Hispanic/Latino heritage groups can facilitate the development of tailored caregiver interventions to address stress associated with being a caregiver and its impact on health.</p>